Table 3.
Outcomes after ischaemic stroke or TIA by 3-month composite persistence
| Outcomes | Composite persistence | N | Events， n (%) |
Model 1* | Model 2† | ||
| Adjusted HR/OR (95% CI) | P value | Adjusted HR/OR (95% CI) | P value | ||||
| Stroke | Level I | 4397 | 134 (3.1) | 1.00 (Ref) | 1.00 (Ref) | ||
| Level II | 5464 | 80 (1.5) | 0.49 (0.37 to 0.64) | <0.001 | 0.41 (0.31 to 0.54) | <0.001 | |
| Level III | 8483 | 101 (1.2) | 0.40 (0.31 to 0.52) | <0.001 | 0.37 (0.28 to 0.48) | <0.001 | |
| Composite events‡ | Level I | 4397 | 159 (3.6) | 1.00 (Ref) | 1.00 (Ref) | ||
| Level II | 5464 | 97 (1.8) | 0.50 (0.38 to 0.64) | <0.001 | 0.41 (0.32 to 0.53) | <0.001 | |
| Level III | 8483 | 125 (1.5) | 0.42 (0.33 to 0.53) | <0.001 | 0.38 (0.30 to 0.49) | <0.001 | |
| All-cause death | Level I | 4397 | 367 (8.4) | 1.00 (Ref) | 1.00 (Ref) | ||
| Level II | 5464 | 120 (2.2) | 0.29 (0.24 to 0.36) | <0.001 | 0.28 (0.23 to 0.35) | <0.001 | |
| Level III | 8483 | 123 (1.5) | 0.20 (0.16 to 0.24) | <0.001 | 0.20 (0.16 to 0.24) | <0.001 | |
| Disability (mRS=3–5) | Level I | 3733 | 595 (15.9) | 1.00 (Ref) | 1.00 (Ref) | ||
| Level II | 5069 | 704 (13.9) | 0.93 (0.82 to 1.06) | 0.26 | 0.89 (0.77 to 1.03) | 0.11 | |
| Level III | 7762 | 1022(13.2) | 0.88 (0.79 to 0.99) | 0.026 | 0.82 (0.72 to 0.93) | 0.003 | |
Composite persistence was defined as the percentage (0% to 100%) of discharge medication classes that patients were still taking at 3 months. Level I: persistence=0%; level II: 0%<persistence<100%; level III: persistence=100%.
HR for stroke, composite events and all-cause death; OR for disability.
*Model 1: adjusted for age and sex.
†Model 2: adjusted for patient and hospital characteristics, including age, sex, ethnicity, education level, health insurance, family income per month, history of hypertension, diabetes, dyslipidaemia, atrial fibrillation, myocardial infarction, coronary artery disease, previous TIA or stroke, ever smoking and drinking, admission NIHSS score, type of disease, severity of illness at discharge, new stroke within 3 months, hospital grade, region, teaching hospital, stroke unit, hospital beds and number of neurological ward beds.
‡Composite events: stroke, myocardial infarction or death from cardiovascular cause.
mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; Ref, reference; TIA, transient ischaemic attack.