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. 2021 May 25;32(6):1067–1077. doi: 10.1021/acs.bioconjchem.1c00123

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PPCs translocation across a bEnd.3 in vitro BBB model. (A) bEnd.3 in vitro BBB model transwell system. The insert, or apex, corresponds to the blood side, while the base (bottom chamber) corresponds to the brain side. (B) After formation of a monolayer, 10 μM of each conjugate was added to the apical side of the tissue culture inserts. After incubation for 24 h, samples from the basolateral side were collected, and the percentage of translocation of each conjugate (black) was calculated. FD4 permeability (gray) was measured to determine monolayer integrity post-PPCs translocation.