Table 2.

Multivariable adjusted HR (95% CI) of mortality associated with replacement of sitting time

	Activity Level (HR (95% CI))b
	Low active	Moderate active	High active
Cancer	No. deaths = 2085	No. deaths = 2904	No. deaths = 2528	pint. a
Model 1
Replace with LPA	0.90 (0.83-0.97)	0.91 (0.88-0.97)	1.01 (0.99-1.07)
Replace with MVPA	0.53 (0.39-0.70)	0.81 (0.70-0.93)	1.00 (0.97-1.06)
Model 2
Replace with LPA	0.91 (0.85-0.97)	0.94 (0.89-0.98)	1.03 (0.98-1.06)	0.0026 LPA
Replace with MVPA	0.69 (0.51-0.94)	0.83 (0.74-0.96)	1.00 (0.97-1.05)	0.0004 MVPA
CVD	No. deaths = 3009	No. deaths = 3548	No. deaths = 2678
Model 1
Replace with LPA	0.81 (0.76-0.86)	0.91 (0.86-0.95)	1.00 (0.96-1.06)
Replace with MVPA	0.44 (0.34-0.56)	0.76 (0.67-0.86)	0.99 (0.95-1.03)
Model 2
Replace with LPA	0.83 (0.79-0.89)	0.91 (0.88-0.96)	1.00 (0.97-1.07)	<0.0001 LPA
Replace with MVPA	0.53 (0.41-0.68)	0.83 (0.72-0.94)	0.99 (0.95-1.04)	<0.0001 MVPA
All other causes	No. deaths = 3722	No. deaths = 4227	No. deaths = 3072
Model 1
Replace with LPA	0.83 (0.78-0.89)	0.94 (0.90-1.00)	0.97 (0.94-1.01)
Replace with MVPA	0.40 (0.32-0.49)	0.79 (0.70-0.88)	0.96 (0.93-0.99)
Model 2
Replace with LPA	0.83 (0.79-0.89)	0.94 (0.90-0.98)	0.97 (0.94-1.01)	<0.0001 LPA
Replace with MVPA	0.48 (0.37-0.59)	0.80 (0.72-0.91)	0.96 (0.93-1.00)	<0.0001 MVPA

Model 1: adjusts for age (continuous) and sex; Model 2: adjusts for age, sex, race (white, other), alcohol use (non-drinker, <1, 1, ≥2 drinks/day, unknown), smoking status (never, current, former), years since quitting among former smokers (<10, 10-19, ≥ 20 years), cigarette frequency and smoking duration among current smokers (<20 cigarettes/day for ≤35 years, <20 cigarettes/day for >35 years, 20+ cigarettes/day for ≤35 years, 20+ cigarettes/day for >35 years), aspirin use (non-user, <15, 15-29, 30+ pills/month, unknown), education (high school or some college, college graduate or higher, unknown), occupational status (employed, not employed/retired), ACS dietary guidelines adherence score (0-<3, 3-<6, ≥6, unknown),⁽¹⁷⁾ comorbidity score (0, 1, ≥2 comorbidities, including high blood pressure, diabetes, and high cholesterol), and BMI (continuous, [kg/m²]).

^ap value for interaction by PA category, boldface indicates statistical significance (p<0.01).

^bPhysical Activity level categories split into approximate tertiles: low active ≤ 17 MVPA min/day, moderate active > 17 to ≤ 38 MVPA min/day, high active > 38 MVPA min/day.

HR = hazard ratio; CI = confidence interval; CVD = cardiovascular disease.