Table 3.
Stratified multivariable adjusted HR (95% CI) of mortality associated with replacement of sitting time
| All-Cause HR (95% CI) | Cancer HR (95% CI) | CVD HR (95% CI) | Other HR (95% CI) | |
|---|---|---|---|---|
| Men (n=22978) | No. deaths=9469 | No. deaths=2409 | No. deaths=3282 | No. deaths=3778 |
| Replace with LPA | 0.91 (0.89-0.93) | 0.91 (0.88-0.98) | 0.88 (0.83-0.91) | 0.93 (0.88-0.97) |
| Replace with MVPA | 0.74 (0.70-0.78) | 0.88 (0.77-0.97) | 0.73 (0.67-0.81) | 0.66 (0.60-0.71) |
| Women (n=37976) | No. deaths=10026 | No. deaths=2580 | No. deaths=3275 | No. deaths=4171 |
| Replace with LPA | 0.89 (0.85-0.92) | 0.92 (0.86-1.00) | 0.89 (0.82-0.94) | 0.84 (0.81-0.89) |
| Replace with MVPA | 0.76 (0.71-0.81) | 0.86 (0.78-0.96) | 0.76 (0.68-0.82) | 0.69 (0.63-0.76) |
| pinta: 0.13 LPA, 0.55 MVPA | pint: 0.89 LPA, 0.86 MVPA | pint: 0.76 LPA, 0.81 MVPA | pint: 0.01 LPA, 0.34 MVPA | |
| Age < 65 (n=15375) | No. deaths=1742 | No. deaths=793 | No. deaths=396 | No. deaths=553 |
| Replace with LPA | 0.94 (0.88-1.01) | 0.94 (0.83-1.04) | 0.97 (0.83-1.13) | 0.91 (0.79-1.06) |
| Replace with MVPA | 0.73 (0.66-0.86) | 0.80 (0.66-0.97) | 0.81 (0.62-1.06) | 0.64 (0.50-0.80) |
| Age 65-<75 (n=33152) | No. deaths=9825 | No. deaths=2838 | No. deaths=3033 | No. deaths=3954 |
| Replace with LPA | 0.90 (0.88-0.94) | 0.91 (0.86-0.97) | 0.89 (0.83-0.94) | 0.91 (0.88-0.97) |
| Replace with MVPA | 0.74 (0.70-0.79) | 0.86 (0.76-0.94) | 0.74 (0.65-0.81) | 0.69 (0.64-0.76) |
| Age ≥ 75 (n=12427) | No. deaths=7928 | No. deaths=1358 | No. deaths=3128 | No. deaths=3442 |
| Replace with LPA | 0.88 (0.85-0.92) | 1.00 (0.83-1.11) | 0.86 (0.81-0.92) | 0.86 (0.80-0.91) |
| Replace with MVPA | 0.74 (0.70-0.79) | 0.97 (0.88-1.06) | 0.76 (0.68-0.83) | 0.65 (0.60-0.72) |
| pint: 0.04 LPA, 0.19 MVPA | pint: 0.50 LPA, 0.15 MVPA | pint: 0.11 LPA, 0.41 MVPA | pint: 0.04 LPA, 0.26 MVPA | |
| Normal weight BMI (n=24663) | No. deaths=8173 | No. deaths=1907 | No. deaths=2678 | No. deaths=3588 |
| Replace with LPA | 0.89 (0.86-0.94) | 0.91 (0.86-1.01) | 0.88 (0.82-0.94) | 0.88 (0.86-0.94) |
| Replace with MVPA | 0.70 (0.66-0.74) | 0.89 (0.79-0.99) | 0.68 (0.61-0.76) | 0.62 (0.56-0.68) |
| Overweight BMI (n=24575) | No. deaths=7645 | No. deaths=2113 | No. deaths=2562 | No. deaths=2970 |
| Replace with LPA | 0.91 (0.88-0.94) | 0.94 (0.88-0.98) | 0.88 (0.83-0.94) | 0.91 (0.86-0.97) |
| Replace with MVPA | 0.78(0.74-0.86) | 0.86 (0.76-0.97) | 0.81 (0.72-0.89) | 0.74 (0.68-0.83) |
| Obese BMI (n=11716) | No. deaths=3677 | No. deaths=969 | No. deaths=1317 | No. deaths=1391 |
| Replace with LPA | 0.89 (0.83-0.94) | 0.91 (0.81-1.00) | 0.86 (0.79-0.97) | 0.89 (0.81-0.97) |
| Replace with MVPA | 0.74 (0.67-0.81) | 0.83 (0.70-0.99) | 0.74 (0.64-0.86) | 0.70 (0.60-0.80) |
| pint: 0.68 LPA, 0.05 MVPA | pint: 0.98 LPA, 0.57 MVPA | pint: 0.57 LPA, 0.23 MVPA | pint: 0.83 LPA, 0.04 MVPA |
Models adjust for age (continuous), sex, race (white, other), alcohol use (non-drinker, <1, 1, ≥2 drinks/day, unknown), smoking status (never, current, former), years since quitting among former smokers (<10, 10-19, ≥ 20 years), cigarette frequency and smoking duration among current smokers (<20 cigarettes/day for ≤35 years, <20 cigarettes/day for >35 years, 20+ cigarettes/day for ≤35 years, 20+ cigarettes/day for >35 years), aspirin use (non-user, <15, 15-29, 30+ pills/month, unknown), education (high school or some college, college graduate or higher, unknown), occupational status (employed, not employed/retired), ACS dietary guidelines adherence score (0-<3, 3-<6, ≥6, unknown),(17) comorbidity score (0, 1, ≥2 comorbidities, including high blood pressure, diabetes, and high cholesterol), and BMI (continuous, [kg/m2]). Only moderate and low active participants included (n=60,954).
p value for interaction by PA category, boldface indicates statistical significance (p<0.05).
HR = hazard ratio; CI = confidence interval; CVD = cardiovascular disease.