Figure 1. Expression levels of miR-92d-3p in the kidneys of patients with DN decreased.
qRT-PCR was used in detecting the expression levels of miR-92d (A), C3 (B), HMGB1 (C), TGF-β1 (D), E-cadherin (E), α-SMA (F), and Col I (G). miR-92d-3p was down-regulated in the renal tissues of patients with DN. The C3/HMGB1/TGF-β1 pathway was activated. Data were expressed as mean ± standard. Control group, n=20; DN group n=22. Compared with the control group, *P<0.05, **P<0.01, ***P<0.001. Student’s t test.