Fig. 3.

Mutational spectrum in pediatric low-grade gliomas. (A) Distribution of molecular alterations in pediatric low-grade gliomas (top¹³) and pilocytic astrocytomas (bottom²⁶). X-axis denotes the percentage of tumors with identified mutations in each cohort (N = 400, pLGGs; N = 96, PAs). (B) Graphic illustration of the MAPK/ERK signaling pathway, highlighting the genetic/genomic alterations commonly observed in these tumors that increase MEK signaling (bold; involving the FGFR1, NTRK2, RAS, BRAF, and NF1 genes). Created with BioRender.com. Abbreviations: MAPK/ERK, mitogen-activated protein kinase/extracellular signal-regulated kinase; PAs, pilocytic astrocytomas; pLGGs, pediatric low-grade gliomas.