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. 2021 Sep 27;20:15330338211041253. doi: 10.1177/15330338211041253

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© The Author(s) 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — ICAT is upregulated in CRC. (A) ICAT expression in various cancers was analyzed by the GEPIA online database. (B) The expression of ICAT in COAD and normal tissues of online data was analyzed. (C) Comparison of the overall survival of low- and high-ICAT expression patients in TCGA database. (D) ICAT expression in normal tissue and cancer in single slice sample. (E) The standard of IHC scores in cancer tissue. (F) Tissue chip analysis showing higher ICAT expression in COAD than in adjacent normal tissues. (G) Comparison of the overall survival of low- and high-ICAT expression patients in the tissue chip. *P < 0.05, ****P < 0.0001.

Abbreviations: ICAT, inhibitor of β-catenin and T-cell factor; CRC, colorectal cancer; GEPIA, gene expression profiling interactive analysis; COAD, colon adenocarcinoma; TCGA, The Cancer Genome Atlas; IHC, immunohistochemistry.