Table 2. Pharmacological treatment of frontotemporal dementia symptoms through drug-class therapeutic response.

Drug class	Results	Studies’ design
Antidepressants (mostly SSRI and trazodone)	Improvement in behavioral symptoms	Case reports and series, open label trials, randomized double-blind placebo-controlled trial12,13,14,23,25,27
Atypical antipsychotics: risperidone, aripiprazole, olanzapine, quetiapine	Improvement in behavioral symptoms	Case reports and series35,38,44,46
Antiepileptics	Improvement in behavioral symptoms	Case reports and series39,40,41
Cholinesterase inhibitors	No improvement in cognition and worsening of behavioral symptoms	Open label trials, randomized, double-blind placebo controlled trials17,26,34
NMDA-antagonist (memantine)	Worsening of cognition and behavioral symptoms	Case series, open label trials, randomized double-blind placebo-controlled trials18,28,29,33

FTD: frontotemporal dementia; NMDA: N-methyl-d-aspartate.