. 2021 Jul-Sep;15(3):331–338. doi: 10.1590/1980-57642021dn15-030004

Table 3. Pharmacological treatments through symptom-focused approach.

bvFTD core symptom	Treatment options	Studies design
Behavioral disinhibition	SSRI and trazodone	Case reports and series, open label trials, randomized double-blind placebo-controlled trial^{12,13,14,23,25,27}
Behavioral disinhibition	Atypical antipsychotics: risperidone, aripiprazole, olanzapine, quetiapine	Case reports and series^35,38,44,46
Compulsive/perseverative behavior	SSRI and trazodone	Case reports and series, open label trials, randomized double-blind placebo-controlled trial trial^{12,13,14,23,25,27}
Hyperorality	Oxytocin, topiramate, SSRI, and trazodone	Case reports and series, open label trials, randomized double-blind placebo-controlled trial trial^{12,13,14,19,23,25,27,41}
Loss of empathy/sympathy	Oxytocin and Fortasyn Connect™	Randomized, double-blind, placebo-controlled studies^19,21
Apathy	Psychostimulants	Randomized, double-blind, placebo-controlled studies and case report^15,16,37,47

bvFTD: behavioral variant frontotemporal dementia; SSRI: selective serotonin reuptake inhibitors.