TABLE 3.

Pharmacologic Treatment for Headache in PED

Medication	Spearman's Coefficient	95% CI	P value	2007 (%)	2014 (%)
Pharmacologic therapy	0.68	−0.05, 0.94	0.06	76	84
Oral treatment	0.26	−0.55, 0.82	0.53	8	16
Any IV treatment	0.30	−0.51, 0.83	0.46	68	68
Acetaminophen	0.17	−0.61, 0.78	0.68	6	10
Dexamethasone	0.17	−0.61, 0.78	0.69	0	0
Diphenhydramine	0.85	0.36, 0.97	0.007	4	50
Ibuprofen	0.29	−0.52, 0.83	0.49	4	10
IVF	0.54	−0.27, 0.90	0.17	62	66
Ketorolac	0.05	−0.68, 0.72	0.91	62	58
Metoclopramide	0.59	−0.2, 0.91	0.12	48	58
Naproxen	0.11	−0.64, 0.76	0.80	2	4
Ondansetron	0.33	−0.49, 0.84	0.42	4	10
Opioid	−0.31	−0.83, 0.50	0.45	2	0
Prochlorperazine	–	–		0	0
Triptan	–	–		0	0
Valproic acid	0.85	0.36, 0.97	0.008	4	16
Migraine Cocktail*	0.56	−0.23, 0.91	0.15	46	56

CI, confidence interval; IV, intravenous; IVF, intravenous fluids.

^*Migraine cocktail was defined by local protocol as metoclopramide or prochlorperazine plus ketorolac and normal saline intravenous fluid bolus with or without diphenhydramine. The components of the migraine cocktail were analyzed individually and as a grouping.

Statistically significant values are bolded.