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. 2020 Aug 27;106(10):2624–2632. doi: 10.3324/haematol.2020.256313

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Copyright© 2021 Ferrata Storti Foundation

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Figure 4. — CDK4 and CDK6 drive the myeloid and lymphoid progenitor pool in opposite directions. Analysis was performed 3 weeks post final polyinosinic–polycytidylic acid (poly(I:C)) injection. Percentage of (A) myeloid progenitors (LKS-) and (B) common lymphoid progenitors (CLP) (Lin^-IL-7R⁺c-Kit^midSca-1^mid) per 2.5x10⁶ bone marrow (BM) cells (Cdk4^Δ/Δ; Cdk6^Δ/Δ; Cdk4/6^fl/fl, n≥5/genotype). Total numbers of (C) CD11b⁺Gr1^hi granulocytes and (D) CD3e⁺ T cells in BM (two femurs and tibias; Cdk4^Δ/Δ; Cdk6^Δ/Δ; Cdk4/6^fl/fl, n≥8/genotype). All comparisons were done with one-way ANOVA followed by Bonferroni’s Multiple Comparison Test, *P≤0.05, **P≤0.01, ***P≤0.001, ****P≤0.0001.