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. 2021 Apr 22;106(10):2654–2666. doi: 10.3324/haematol.2021.278427

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Copyright© 2021 Ferrata Storti Foundation

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Figure 7. — Clonal architecture of B lineage repertoires and lymphocyte-predominant-cell clone/ non-Hodgkin lymphoma malignant clone subclones in nodular lymphocyte- predominant Hodgkin lymphoma with transformation to non-Hodgkin lymphoma (cohort 3). (A) Cases with identical rearrangement. (B) Cases with different rearrangements. IGHV/D/J map of the global IGH repertoire are shown. Rearrangement of IGHV1-7 main groups and IGHJ1-6 are plotted on the vertical axis. IGHD subgroups are plotted on the horizontal axis. Each dot represents one immunoglobulin rearrangement colored according to its CDR3 length and sized according to clonal fraction. A white square indicates the position of the malignant clone. A schematic overview of intraclonal diversification and evolutionary patterns of lymphocyte- predominant-cell clone/ non-Hodgkin lymphoma malignant clone (LP/NHL clone) subclones derived from the same cell of origin is shown below. The size of the bubbles reflects relative clone fractions of LP/NHL subclones within one repertoire. Arrows indicate somatic hypermutation. Colored clones are further characterized in Table 1. NLPHL: nodular lymphocyte-predominant Hodgkin lymphoma; Trafo: transformation.