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. 2021 May 13;106(10):2746–2748. doi: 10.3324/haematol.2021.278573

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Copyright© 2021 Ferrata Storti Foundation

This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

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Figure 1. — Interferon-I signature and kinetics of SARS-CoV-2 serology in sickle cell disease patients. (A) Interferon-I (IFN-I) signature in 25 sickle cell disease (SCD) patients according to age. IFN-I signature was considered increased above a score of 2.3. (B) Basal IFNα concentration in plasma from healthy donors (AA, n=34) and SS patients (SS, n=25) using a digital enzyme-linked immunsorbent assay (SIMOA). (C) Evolution of serological titer (immunoglobulin G [IgG]) in 17 SCD patients following the first wave of the SARSCoV- 2 epidemic. The different zones represent the level of IgG titers and interpretation: grey: negative IgG titers; yellow: intermediate IgG titers; red: positive IgG titers.