Table 4:

Normalized Pharmacokinetic Parameters to 2.5 mg/kg for 75 kg

Data Points	Raw Dose (mg)	Dose-normalized Dose (mg)	Dose-normalized Cmax (ng/mL)	Tmax (hrs)	Dose-normalized AUC(0-∞) (h*ng/mL)
Predicted Fasted	187.5	187.5	81.723	0.5	-
Predicted Fed	187.5	187.5	300.63	2.5	-
A1	750	187.5	84.05	5.12	420.83
A2	1500	187.5	131.13	6.13	339.13
A3	4500	187.5	106.73	4.07	95.43
B1	1500	187.5	210	5	-
B2	1500	187.5	213	4.5	-
B3	1500	187.5	209.5	5	-
C	800	187.5	18.26	3	-
D1	10	187.5	39.38	1	58
D2	10	187.5	9.38	3	129
E1	400	187.5	84.94	3	3300
E2	800	187.5	51.82	3	2032
F1	10	187.5	46.94	1.63	8012
F2	10	187.5	56.63	2.8	7646
F3	10	187.5	48.94	2.05	9318
F4	10	187.5	46.31	1.27	6788
G	10	187.5	26.34	1.38	-
H1	1500	187.5	36.55	4	202.25
H2	3000	187.5	33.31	5	175.13
H2	4500	187.5	30.09	5	142.75
H4	6000	187.5	24.44	5	121.88
H5	1500	187.5	41.93	3.5	274.75
H6	1500	187.5	203.5	3	1083.63
H7	750	187.5	82.58	3	-
H8	1500	187.5	67.65	3	-
I1	45	187.5	70	1.88	-
I2	90	187.5	113.75	2.05	-
I3	45	187.5	88.33	2.17	-
I4	90	187.5	161.67	1.83	-
J1	10	187.5	60.38	3	193.31
J2	100	187.5	88.95	3.5	286.95
J3	10	187.5	38.44	3.5	146.44
K1	5	187.5	14.63	1	62.25
K2	10	187.5	21.56	1.38	105.75
K3	20	187.5	20.34	1	124.5
K4	5	187.5	18.38	1.64	-
K5	10	187.5	21.38	1.27	-
K6	20	187.5	30.19	2	-
L1	200	187.5	218.44	2.8	655.31
L2	200	187.5	331.88	2	1090.31
L3	200	187.5	357.19	2.5	2337.19
L4	200	187.5	138.75	2.33	444.38
M1	300	187.5	5.63	3.2	353.77
M2	300	187.5	84.38	2.4	481.88
N	10	187.5	62.44	4.22	808267.5

Dose- and patient weight-normalized values correspond to the Population Pharmacokinetic (PopPK) plot generated by E.C. and transposed by A.W.