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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Pharmacotherapy. 2021 Mar 18;41(4):405–420. doi: 10.1002/phar.2512

Table 4:

Normalized Pharmacokinetic Parameters to 2.5 mg/kg for 75 kg

Data Points Raw Dose (mg) Dose-normalized Dose (mg) Dose-normalized Cmax (ng/mL) Tmax (hrs) Dose-normalized AUC(0-∞) (h*ng/mL)

Predicted Fasted 187.5 187.5 81.723 0.5 -
Predicted Fed 187.5 187.5 300.63 2.5 -

A1 750 187.5 84.05 5.12 420.83
A2 1500 187.5 131.13 6.13 339.13
A3 4500 187.5 106.73 4.07 95.43
B1 1500 187.5 210 5 -
B2 1500 187.5 213 4.5 -
B3 1500 187.5 209.5 5 -
C 800 187.5 18.26 3 -
D1 10 187.5 39.38 1 58
D2 10 187.5 9.38 3 129
E1 400 187.5 84.94 3 3300
E2 800 187.5 51.82 3 2032
F1 10 187.5 46.94 1.63 8012
F2 10 187.5 56.63 2.8 7646
F3 10 187.5 48.94 2.05 9318
F4 10 187.5 46.31 1.27 6788
G 10 187.5 26.34 1.38 -
H1 1500 187.5 36.55 4 202.25
H2 3000 187.5 33.31 5 175.13
H2 4500 187.5 30.09 5 142.75
H4 6000 187.5 24.44 5 121.88
H5 1500 187.5 41.93 3.5 274.75
H6 1500 187.5 203.5 3 1083.63
H7 750 187.5 82.58 3 -
H8 1500 187.5 67.65 3 -
I1 45 187.5 70 1.88 -
I2 90 187.5 113.75 2.05 -
I3 45 187.5 88.33 2.17 -
I4 90 187.5 161.67 1.83 -
J1 10 187.5 60.38 3 193.31
J2 100 187.5 88.95 3.5 286.95
J3 10 187.5 38.44 3.5 146.44
K1 5 187.5 14.63 1 62.25
K2 10 187.5 21.56 1.38 105.75
K3 20 187.5 20.34 1 124.5
K4 5 187.5 18.38 1.64 -
K5 10 187.5 21.38 1.27 -
K6 20 187.5 30.19 2 -
L1 200 187.5 218.44 2.8 655.31
L2 200 187.5 331.88 2 1090.31
L3 200 187.5 357.19 2.5 2337.19
L4 200 187.5 138.75 2.33 444.38
M1 300 187.5 5.63 3.2 353.77
M2 300 187.5 84.38 2.4 481.88
N 10 187.5 62.44 4.22 808267.5

Dose- and patient weight-normalized values correspond to the Population Pharmacokinetic (PopPK) plot generated by E.C. and transposed by A.W.