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Proliferating versus nonproliferating cells have different metabolic needs. Nonproliferating cells do not have an excessive need to conduct anabolic functions, thus they catabolize their nutrients to generate ATP and NADPH for housekeeping functions. In contrast, proliferating cells engage in a massive anabolic program to generate lipids, proteins, and nucleotides. (Adapted from Vander Heiden 2011, by permission from Macmillan Publishers Ltd.)
