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. 2021 Oct 1;3:45. doi: 10.1186/s42238-021-00101-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Inhalant cannabichromene (CBC) improved pulmonary function. A Treating mouse model of acute respiratory distress syndrome (ARDS) with inhalant CBC, specifically designed cone-shaped spout of the inhaling device (ApelinDx^tm) connected to spacer completely sealed for a soft, comfortable, and insuring delivery of inhalant CBC to the mice. B Blood oxygen saturation was increased by ~8% towards a normal level (Blue bar) in mice treated with Poly (I:C) (PIC) followed by the treatment of inhalant CBC (PIC + CBC) (Green bar) compared to the untreated group (PIC) (Red bar) (**p<0.05, bars show means +/− standard deviation, SD). C Histological analysis, hematoxylin and eosin (H&E upper panels), and Masson’s trichrome (MT lower panels) demonstrated that Poly (I:C) caused the destruction of morphology and architecture of lung in mice with ARDS compared to the normal control group (sham). Inhalant CBC was able to improve the lung structure towards a normal status (PIC + CBC)