TABLE 3.

Proposed Retreatment Criteria for HBeAg‐Negative Patients After NA Discontinuation^{( 62 )}

NA treatment should be immediately re‐installed if one of the following criteria is met:

1. Confirmed (i.e., two consecutive central laboratory results) increase in direct bilirubin from baseline and ALT ULN at the confirmatory test

2. Confirmed sustained increase in prothrombin time ≥ 2.0 seconds from baseline with appropriate vitamin K levels and elevated ALT

3. Confirmed elevated ALT 10× ULN with or without associated symptoms

4. ALT 2× ULN and ≤ 5× ULN persisting for ≥ 84 days (12 weeks) as well as an HBV‐DNA relapse ≥ 20,000 copies/mL

5. ALT 5× ULN and ≤ 10× ULN persisting for ≥ 28 days (4 weeks)