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Dose escalation in the single ascending dose study.
| Subjects (n = 40) | Dose administered | |||||||
|---|---|---|---|---|---|---|---|---|
| Cohort 1 (n = 8, 6:2) | Dose 1 | Dose 4 | ||||||
| 5 mg | 100 mg | |||||||
| Cohort 2 (n = 8, 6:2) | Dose 2 | Dose 5 | ||||||
| 25 mg | 200 mg | |||||||
| Cohort 3 (n = 8, 6:2) | Dose 3 | Dose 6 | ||||||
| 50 mg | 400 mg | |||||||
| Cohort 4 Elderly cohort (n = 16, 12:4) | Dose A | Dose B | ||||||
| 50 mg | 150 mg | |||||||
