TABLE 2.

Demography and baseline characteristics.

Variable	Categories	SAD					MAD
		Adult (Part A)		Elderly (Part A)		Food effect (Part B)
		TRC150094	Placebo	TRC150094	Placebo	100 mg	TRC150094	TRC150094	Placebo
		5–400 mg	(N = 6)	50/150 mg	(N = 4)	(N = 6)	50 mg	150 mg	(N = 7)
		(N = 18)		(N = 12)			(N = 12)	(N = 9)
Gender, n (%)	Female	12 (66.7)	4 (66.7)	5 (41.7)	2 (50.0)	3 (50.0)	3 (33.3)	4 (44.4)	2 (22.2)
	Male	6 (33.3)	2 (33.3)	7 (58.3)	2 (50.0)	3 (50.0)	9 (47.4)	5 (26.3)	5 (26.3)
Race, n (%)	Black/African	1 (5.6)	3 (50.0)	0	0	1 (16.7)	0	0	0
	Other (African/White) Mixed	1 (5.6)	0	0	0	1 (16.7)	0	0	0
	Other: Metis	0	0	1 (8.3)	0	0	0	0	0
	Other: West Indies	1 (5.6)	0	0	0	0	0	0	0
	White	15 (83.3)	3 (50.0)	11 (91.7)	4 (100.0)	4 (66.7)	0	0	0
	Indian	0	0	0	0	0	12 (100)	9 (100)	7 (100)
Age (years) *	All Subjects	46.1 (15.3)	42.3 (19.1)	70.4 (4.8)	69.5 (0.5)	50.0 (7.7)	39.7 (11.8)	46.0 (5.7)	45.1 (10.5)
Height (cm) *	All Subjects	167.9 (6.5)	165.3 (6.2)	164.8 (10.3)	161.5 (7.1)	165.7 (7.9)	164.9 (7.8)	161.2 (6.7)	161.3 (7.8)
Weight (kg) *	All Subjects	86.5 (15.0)	79.0 (8.2)	77.8 (12.0)	72.5 (4.4)	63.8 (10.0)	84.3 (10.0)	77.3 (6.7)	82.6 (12.3)
BMI (kg/m 2 ) *	All Subjects	30.6 (3.9)	28.9 (2.6)	28.5 (1.6)	27.8 (0.8)	23.2 (2.1)	30.9 (2.4)	29.8 (2.6)	31.6 (2.4)
Smoking status, n (%)	Smoker	2 (11.1)	2 (33.3)	2 (16.7)	0 (0.0)	-	0 (0.0)	0 (0.0)	1 (14.3)
	Ex-smoker	6 (33.3)	2 (33.3)	5 (41.7)	1 (25.0)	-	3 (25.0)	1 (11.1)	0 (0.0)

N = Number of subjects with non-missing values; n/% = Number/percentage of subjects with the given characteristics; * = Mean (SD).

Abbreviations: BMI, body mass index; SAD, single ascending dose; MAD, multiple ascending doses.