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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Oncol Res. 2009;18(4):173–184. doi: 10.3727/096504009790217399

Fig. 3– LPA and S1P exhibit differential migratory activities on breast cancer cells.

Fig. 3–

MDA-BO2 cells were seeded on higher (High) and/or lower (Low) chambers of transwell migration chambers. No lysolipid (LLP) or S1P (10−7M) or LPA (10−7M) were added on indicated chambers. LPA exhibits both chemotactic and chemokinetic activities, whereas S1P acts only as a chemo-attractant factor on MDA-BO2 cells. Cells that have passed through the 8 μm membrane were enumerated after 6 hours of treatment. Data are expressed as number of cells/mm2. Bars represent means ± SD of at least three experiments. *, P<0.001 compared to control condition in absence of lysolipid.