Table 1.

Classification of the Cardiac ECM-associated Proteins

	Classification	ECM-associated Proteins
Glycoproteins	Structural proteins	Collagen type I, III, V
	Nonstructural proteins	Collagen type IV, VI
	Matricellular proteins	Tenascin, thrombospondins, SPARC, periostin osteopontin, members of the CCN family
	Basement membrane proteins	Fibronectin, laminin, collagen type IV
	Matricryptins	Endostatin, tumstatin
	Others	Elastin, fibronectin, laminin, fibrillin
Proteoglycans	ECM-associated proteoglycans	Aggrecan, versican, perlecan, nidogen
	Basement membrane–associated proteoglycans	Heparin sulfate (agrin, perlecan), collagen type XVIII, nidogen
	Cell surface–associated proteoglycans	Syndecan, Glypican
	Glycosaminoglycans	Hyaluronate, chondrotin sulfate, heparin sulfate, dermatan sulfate
	Proteases and their inhibitors	MMPs, TIMPs, ADAMS, ADAMTS
	Small leucine rich–associated proteoglycans	Biglycan, podocan, asporin, fibromodulin, decorin

Definition of abbreviations: ADAMS = a disintegrin and metalloproteinase with thrombospondin motifs; CCN = Cyr61 (cysteine-rich 61)/βIG-M1/Cef10/CCN1, CTGF (connective tissue growth factor)/Hcs-24(hypertrophic chondrocyte-specific gene 24)/βIG-M2/Fisp-12/HBGF-0.8/CCN2, and Nov (nephroblastoma overexpressed)/CCN3; ECM = extracellular matrix; MMP = matrix metalloproteinase; SPARC = secreted protein acidic and rich in cysteine; TIMP = tissue inhibitor of metalloproteinases.