Table 1.

Pharmacokinetics of [⁶⁴Cu]Cu-NOTA-aCD40.

Parameters
t1/2α (h)	0.6 ± 0.05
t1/2β (h)	65.9 ± 64.6
V1 (mL)	2 ± 0
Vss (mL)	1232 ± 605
CLtotal (mL/h)	0.3 ± 0.1
AUCtotal (%ID/mL × h)	347 ± 190

Data were fitted using a two-compartment model with i.v. bolus input.

t_1/2,α = alpha phase half-life, t_1/2,β = beta phase half-life, V1 = volume of distribution (central compartment), Vss = volume of distribution at steady-state, CLtotal = clearance, and AUCtotal = area under the curve.