Table 4.
The cross-talk between the PD-L1/PD-1 axis and tumor-infiltrating CD8+ T-cells in glioblastoma.
| First author, year | Country | Sample size | Tumor type | Cross-talk between the PD-L1/PD-1 axis and tumor-infiltrating CD8+ T-cells | P-value | HR, and 95% CI | OR, CI 95% | r |
|---|---|---|---|---|---|---|---|---|
| Berghoff, 2015 ( 20 ) | Austria | 135 | Glioblastoma | Tumor-infiltrating PD-1+ lymphocytes are correlated with tumor-infiltrating CD8+ PD-1+ cells. | P<0.001 | Not applicable | Not applicable | Not provided |
| Berghoff, 2015 ( 20 ) | Austria | 135 | Glioblastoma | There is no statistically significant association between diffuse/fibrillary PD-L1 and tumor-infiltrating CD8+ T-cells. | P=0.068 | Not applicable | Not applicable | Not provided |
| Berghoff, 2015 ( 20 ) | Austria | 135 | Glioblastoma | There is no statistically significant association between membranous PD-L1 and tumor-infiltrating CD8+ T-cells. | P=0.380 | Not applicable | Not applicable | Not provided |
| Zhang, 2017 ( 23 ) | China | 17 | Glioblastoma | There is no statistically significant association between tumoral PD-L1 and tumor-infiltrating CD8+ T-cells. | P=0.4959 | Not applicable | 3, and 0.1270 - 70.8770 | Not provided |
| Su, 2019 ( 16 ) | China | 47 | Glioblastoma | The PD-L1 expression is inversely correlated with tumor-infiltrating CD8+ T-cells. | P=0.0003 | Not applicable | Not applicable | r = -0.5064 |
| Su, 2019 ( 16 ) | China | 47 | Glioblastoma | The low expression of PD-L1 and high level of tumor-infiltrating CD8+ T-cells are associated with improved OS. | P<0.05 | Not provided | Not applicable | Not applicable |
| Su, 2019 ( 16 ) | China | 47 | Glioblastoma | The survival rate of patients with low PD‐L1 expression and low CD8+ infiltration is similar to those with high PD‐L1 expression and low CD8+ infiltration. | P<0.05 | Not provided | Not applicable | Not applicable |
| Jan, 2018 ( 21 ) | Taiwan | 20 | Glioblastoma | A high PD-1+/tumor-infiltrating CD8+ T-cell ratio is associated with worse OS. | P<0.001 | 11.382, and 3.320–35.707 | Not applicable | Not applicable |
| Jan, 2018 ( 21 ) | Taiwan | 20 | Glioblastoma | A high PD-1+/tumor-infiltrating CD8+ T-cell ratio is associated with worse PFS. | P=0.01 | 3.458, and 1.304–9.174 | Not applicable | Not applicable |
| Jan, 2018 ( 21 ) | Taiwan | 27 | Glioblastoma | A high PD-1+/tumor-infiltrating CD8+ T-cell ratio is not statistically associated with OS. | P-value = 0.23 | 0.567, and 0.224–1.437 | Not applicable | Not applicable |
| Jan, 2018 ( 21 ) | Taiwan | 27 | Glioblastoma | A high PD-1+/tumor-infiltrating CD8+ T-cell ratio is not statistically associated with PFS. | P=0.44 | 1.205, and 0.753–1.929 | Not applicable | Not applicable |
| Jan, 2018 ( 21 ) | Taiwan | 27 | Glioblastoma | The PD-1+/tumor-infiltrating CD8+ T-cell ratio is inversely associated with OS. | P<0.001 | Not applicable | Not applicable | r = -0.655 |
| Jan, 2018 ( 21 ) | Taiwan | 27 | Glioblastoma | The PD-1+/tumor-infiltrating CD8+ T-cell ratio is inversely associated with PFS. | P=0.02 | Not applicable | Not applicable | r = -0.444 |
OS, Overall survival; PD-L1, Programmed death-ligand 1; PFS, Progression-free survival; PD-1, Programmed cell death protein 1; HR, Hazard ratio; CI, Confidence interval; and CD, Cluster of differentiation.