. 2021 Oct 1;16(10):e0257911. doi: 10.1371/journal.pone.0257911

Table 4. Summary of interactions of relevant genes for various drugs in hypomorph library with 162 essential genes.

drug	# genes with significant negative interactions (Zrobust<-3.5, Padj<0.05)	known target of drug	genes related to drug mechanism of action #rank (Zrobust)
levofloxacin	9	*gyrA*	#4: *gyrA* (-4.6)—DNA gyrase
moxifloxacin	10	*gyrA*	#8: *gyrA* (-5.5)—DNA gyrase
isoniazid	9	(inhA) ^*	#2: *ino1* (-19.6)—inositol-3-phosphate synthase
isoniazid	9	(inhA) ^*	#11: *kasB* (-4.4)—ketoacyl synthase
fidaxomicin	7	*rpoB*	#9: *rpoB* (-5.0)—RNA polymerase beta subunit
sulfamethoxazole	20	(folP1) ^*	#7: *thyA* (-11.1)–thymidylate synthase
bedaquiline	4	(atpE)^*	#9: *atpB* (-2.8^†)—subunit of ATP synthase
			#13: *atpH* (-2.2^†)—subunit of ATP synthase
			#23: *atpF* (-1.3^†)—subunit of ATP synthase
			#38: *atpG* (-0.8^†)—subunit of ATP synthase

† does not exceed the outlier cutoff of Zrobust<-3.5, but still has a negative slope showing synergy with the drug

* gene not represented in hypomorph library