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. 2021 Oct 1;18(10):e1003769. doi: 10.1371/journal.pmed.1003769

Fig 3. SARS-CoV-2 anti-spike IgG and neutralizing antibody responses at Day 35.

Fig 3

Shown are geometric mean anti-spike IgG ELISA unit responses to the NVX-CoV2373 protein antigen (Panel A) for younger adult and older adult age groups in the phase 2 study for the 2-dose primary vaccination treatment regimens (Groups B and D), along with aligned group results by the same assay in the phase 1 study, and wild-type SARS-CoV-2 MN assay at an inhibitory concentration >50% (MN50) titer responses (Panel B) for younger adult and older adult age groups in the phase 2 study. These panels also include immune responses from a panel of participants by age group from a clinical case series of participants (see Methods). In Panels A and B, boxes and horizontal bars represent IQR and median area under the curve, respectively. Whisker endpoints are equal to the maximum and minimum values below or above the median ± 1.5 times the IQR. (A) SARS-CoV-2 anti-spike IgG ELISA. (B) Wild-type SARS-CoV-2 MN. CI, confidence interval; ELISA, enzyme-linked immunosorbent assay; EU, endotoxin unit; GMT, geometric mean titer; IC, inhibitory concentration; IgG, immunoglobulin G; IQR, interquartile range; MN, microneutralization; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.