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. 2021 Oct 1;16(10):e0254985. doi: 10.1371/journal.pone.0254985

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© 2021 Taghavi et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — Because fk-652 is a human protein, we are able to differentiate between exogenous IL-22:Fc and endogenous IL-22:Fc. Treatment with IL-22:Fc appears to result in increased endogenous mouse IL-22 (C). Exogenous human IL-22 was detected in the BAL of treated mice (A and B) demonstrating that exogenous IL-22:Fc is reaching the lung. D) Endogenous mouse IL-22:Fc was not increased in IL-22:Fc treated after high-dose LPS injury.