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. 2021 Apr 23;64(10):6937–6948. doi: 10.1021/acs.jmedchem.1c00484

Figure 5.

Figure 5

Prevention of THC-induced amnesic effects by peptide 17, while maintaining THC analgesic responses. (a) Analgesic effects of THC (10 mg/kg, IP) in the mouse hot-plate test were preserved after pretreatment with peptides 17 and 18 (both 20 mg/kg, IV). (b) Amnesic effects of THC (3 mg/kg, IP) observed in the mouse novel object recognition test were abrogated by pretreatment with 17 (20 mg/kg, IV) but not with 18 (20 mg/kg, IV). Data are presented as mean ± SEM (n = 10–12). *p < 0.05 vs vehicle + vehicle (Fisher LSD test).