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. 2021 Apr 23;64(10):6937–6948. doi: 10.1021/acs.jmedchem.1c00484

Figure 6.

Figure 6

Prevention of THC-induced amnesic effects by peptide 17 administered orally, while maintaining THC analgesic responses. (a) Analgesic effects of THC (10 mg/kg, IP) revealed in the mouse hot-plate test were preserved after pretreatment with 17 (5, 10, and 20 mg/kg, OR). (b) Amnesic effects of THC (3 mg/kg, IP) observed in the mouse novel object recognition test were abrogated by pretreatment with 17 (5, 10, and 20 mg/kg, OR). Data are presented as mean ± SEM (n = 5–8). **p < 0.01, ***p < 0.001 vs vehicle + vehicle. #p < 0.05 vs vehicle + THC (Fisher LSD test).