FIGURE 2.

Receptors that facilitate selective autophagy by localizing cargo and binding to ubiquitin, and their interaction with ATG8 family proteins. A, Ubiquitin‐binding (left) and cargo‐localizing (right) receptors. B, Binding of AIM to ATG8. AIM adopts an elongated β‐conformation and forms an intermolecular β‐sheet with β2 of ATG8. In addition, the W/Y/F‐X‐X‐L/I/V side chain of the sequence binds to the W‐site between the N‐terminal helix (α1, α2) and the ubiquitin fold, and the L/I/V side chain binds to the L‐site between β2 and α3 in the ubiquitin fold. AIMs often contain acidic or phosphorylated residues that act to enhance affinity by interacting electrostatically with conserved basic residues in ATG8