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Pyroptotic signaling. When stimulated, caspase‐1 and caspase‐4/‐5/‐11 could cleave GSDMD and caspase‐3 could cleave GSDME to induce pyroptosis. Caspase‐8 can cleave GSDMD and GSDME. Gzm‐A cleaves GSDMB to induce pyroptosis. Gzm‐B could activate or directly cleave GSDME to induce pyroptosis
