TABLE 1.
Inflammasome‐mediated pyroptosis promotes tumor development
| Stimulation factor | Pyroptotic signaling | Pro‐inflammatory cytokines | Normal cells | Cancer cells | Reference |
|---|---|---|---|---|---|
| ‐ | NLRP3‐mediated | IL‐1β | Head and neck squamous cell | Head and neck squamous cell carcinoma | (31) |
| Alcohol | Caspase‐1‐mediated | IL‐1β and IL‐18 | Esophagus | Esophagus cancer | (32) |
| ‐ | Caspase‐1‐dependent | IL‐1β and IL‐18 | Barrett's esophagus | Esophagus cancer | (33) |
| ‐ | GSDMD‐mediate | IL‐1β | Lung | Non‑small‐cell lung cancer | (34) |
| Helicobacter pylori | NLRP3‐mediate | IL‐1β and IL‐18 | Stomach | Gastric cancer | (35) |
| ‐ | Caspase‐1‐mediate | ‐ | Hepatocyte | Human hepatocellular carcinoma | (36) |
| Hepatitis C virus | NLRP3‐mediate | ‐ | Hepatocyte | Human hepatocellular carcinoma | (37) |
| ‐ | Caspase‐1‐mediate | ‐ | Pancreas | Pancreatic ductal adenocarcinoma | (38) |
| ‐ | Caspase‐1‐mediate | IL‐1β | Melanoma | Melanoma | (39) |
| ‐ | NLRP3‐mediate | IL‐1β | Breast cell | Breast cancer | (40) |
| ‐ | ‐ | IL‐1β | Breast cell | Breast cancer | (41) |
| ‐ | Caspase‐1‐mediate | IL‐1 | Human cutaneous squamous cell | Human cutaneous squamous cell carcinoma | (42) |
| High‐risk human papillomaviruses | ‐ | IL‐1β | Anogenital | Anogenital cancer | (43) |
The activation of inflammasome could trigger caspase‐1‐mediated pyroptosis and promote tumor development.