TABLE 3.
Diagnostic value of the five microRNA (miRNA) prediction models in head and neck squamous cell carcinoma
| miRNA | Optimal cut‐off point | Sensitivity (%) | Specificity (%) | AUC (95% CI) | P value | Diagnostic models |
|---|---|---|---|---|---|---|
| hsa‐miR‐27b‐3p | >86 | 43.8 | 100 | 0.725 (0.62‐0.81) | <.001 | miR27b‐3p‐score = −0.59397*miR27b‐3p + 1.62739 |
| hsa‐miR‐491‐5p | >83 | 46.6 | 100 | 0.727 (0.62‐0.81) | <.001 | miR491‐5p‐score = 0.2328*miR491 + 2.25555 |
| hsa‐miR‐1910‐5p | >83 | 67.1 | 90 | 0.829 (0.73‐0.90) | <.001 | miR1910‐5p‐score = 0.78607*miR1910 + 3.63685 |
| hsa‐miR‐630 | >79 | 61.6 | 95 | 0.790 (0.70‐0.87) | <.001 | miR‐630‐score = 0.9375*miR630 + 6.85766 |
| Two‐miRNA panel (miR‐27b‐3p and miR‐1910‐5p) | >78 | 79.5 | 95 | 0.888 (0.80‐0.94) | <.001 | Two‐miR‐score = 0.83708*miR1910 + (−0.68295*miR27b) + 4.26134 |
Abbreviations: AUC, area under the receiver operating characteristic curve; CI, confidence interval.