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. 2021 Aug 22;112(10):4270–4280. doi: 10.1111/cas.15065

TABLE 3.

Prognostic factors for recurrence and PD after surgical resection in clinicopathological characters of 6 and 1 mo post‐operation

Prognostic factors POM6 POM1
n (%) Univariate Multivariate n (%) Univariate Multivariate
P‐value P‐value OR (95%CI) P‐value P‐value OR (95%CI)

Sex

(Male/Female)

56 (54.4)

47 (45.6)

 .70

56 (54.4)

47 (45.6)

 .70

Age (years)

(75≧/<75)

24 (23.3)

79 (76.7)

 .43

24 (23.3)

79 (76.7)

 .43
Primary tumor location (Colon/Rectum)

52 (50.5)

51 (49.5)

 .97

52 (50.5)

51 (49.5)

 .97

Pathological T stageb

(T3+T4/T1+T2)

63 (61.2)

40 (38.8)

 <.01** .07 –

63 (61.2)

40 (38.8)

 <.01** .14 –

Pathological N stageb

(N1 + N2/N0)

36 (35.0)

67 (65.0)

 .01* .29 –

36 (35.0)

67 (65.0)

 .01* .66 –

Venous invasion

(Positive/Negative)

69 (67.0)

34 (33.0)

 .048* .53 –

69 (67.0)

34 (33.0)

 .048* .68 –

Lymphatic invasion

(Positive/Negative)

70 (68.0)

33 (32.0)

 <.01** .61 –

70 (68.0)

33 (32.0)

 <.01** .35 –

Postoperative chemotherapy

(Present/Absent)

44 (42.7)

59 (57.3)

 .96

44 (42.7)

59 (57.3)

 .96

Postoperative CEA level

(Elevated/normal)

19 (18.4)

84 (81.6)

 .01* .04* 4.45 (1.10‐ 19.76)

13 (12.6)

90 (87.4)

 .04* .04* 5.04 (1.9‐24.79)

Postoperative CA19‐9 level

(Elevated/normal)

9 (87.3)

94 (91.3)

 .17

7 (6.8)

96 (93.2)

 .28

Postoperative change in plasma miR21‐5p levela

Elevated/Normal)

34 (33.0)

69 (67.0)

 <.01** <.01** 7.09 (1.64‐41.82)

39 (37.9)

64 (62.1)

 <.01** .03* 4.33 (1.15‐18.86)

Abbreviations: OR, Odds ratio; 95% CI, 95% confidence interval; CEA, Carcinoembryonic antigen level, normal upper limit at 5 ng/mL; CA19‐9, Carbohydrate antigen 19‐9 level, normal upper limit at 37 ng/mL.

*P < .05; **P < .01.

a

−∆∆Ct value = ‐{(CtmiR21‐5p‐CtmiR16‐5p)postoperative‐(CtmiR21‐5p‐CtmiR16‐5p)preoperative}, cut off value = +0.54.

b

UICC TNM classification (the 8th edition).