FIGURE 2.

Stomatin‐mediated inhibitory mechanism of tumor growth. A, Schematic models of stomatin. C, palmitoylated cysteine; CC, coiled‐coil domain; IM, intramembrane domain; SPFH, stomatin, prohibitin, flotillin, and HflK/C domain. B, Increased stomatin expression induced by the cancer cell‐stromal cell contact inhibits Akt activation by decreasing PDPK1 expression, followed by suppression of cancer cell proliferation and induction of apoptosis. In contrast, loss of stomatin facilitates tumor growth