FIGURE 3.

Iron overload leads to ROS and 8‐oxodG. Reactive oxygen species (ROS) can be induced by iron and contribute to the formation of mutagenic 8‐oxo‐7‐hydro‐2′‐deoxyguanosine (8‐oxodG), which leads to hepatocarcinogenesis (HCC) in patients with chronic hepatitis C (CHC)/non‐alcoholic steatohepatitis (NASH), and leukemic transformation in myelodysplastic syndrome (MDS). Therapeutic iron reduction contributes to inhibiting both hepatocarcinogenesis in CHC/NASH and leukemic transformation in MDS