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. 2021 Aug 23;112(10):4198–4207. doi: 10.1111/cas.15101

FIGURE 5.

FIGURE 5

Blockade of hypoxia‐induble factor 1α (HIF1α) inhibited tumor growth and lung metastasis. A, Tumor volume of HCT116‐bearing mice treated with PBS, 5‐fluorouracil (5‐FU), GN44028 (GN), or 5‐FU combined with GN44028. B, Overall survival of HCT116‐bearing mice treated with PBS, 5‐FU, GN, or 5‐FU+GN. C, Tumor volume of HCT116‐bearing mice treated with PBS, oxaliplatin (OX), GN, or GN+OX. D, Overall survival of HCT116‐bearing mice treated with PBS, OX, GN, or GN+OX. E, Tumor volume of CT26‐bearing mice treated with PBS, 5‐FU, GN, or 5‐FU+GN. F, Overall survival of CT26‐bearing mice treated with PBS, 5‐FU, GN, or 5‐FU+GN. G, H&E staining of lung tissues and metastatic pulmonary nodule numbers in CT26‐bearing mice treated with PBS, 5‐FU, GN, or 5‐FU+GN. Scale bar, 100 μm. *P < .05. **P < .01