FIGURE 4.

Silent information regulator 2 (SIRT2) inhibited clear cell renal cell carcinoma cell apoptosis. A, B, Apoptosis of stably transfected ACHN, 786‐O, and Caki‐1 cells was (A) measured by flow cytometry and (B) statistically analyzed. C, D, TUNEL assays were used to (C) observe the apoptotic cells and (D) record the number of TUNEL‐positive cells. Bars represent the means ± SD. Data represent three independent experiments, each carried out in triplicate. *P < .05, **P < .01, ***P < .001 vs corresponding controls (unpaired‐sample Student’s t test). KD, knockdown; OE, overexpression