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. 2021 Aug 10;112(10):4176–4186. doi: 10.1111/cas.15089

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© 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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POU4F2 is a tumor promotor in lung metastatic nude mice. A, Lung weight and number of lung metastatic nodes in BALB/c athymic nude mice injected with HCT116 cells transfected with shNC, shPOU4F2‐1, and shPOU4F2‐2. B, Expression of POU4F2 in lung metastatic nodes for each nude mouse. C, Expression of E‐cadherin and vimentin in lung metastatic nodes for each nude mouse. D, Immunofluorescence staining to evaluate the levels of E‐cadherin and vimentin. Fluorescent DAPI staining of cell nucleus (blue) and antibodies against E‐cadherin or vimentin (red). All experiments were performed in triplicate. Data are presented as the mean ± SEM (*P < .05)