TABLE 1.
Clinicopathologic characteristics of patients with oropharyngeal cancer stratified by human papillomavirus 16 (HPV16) DNA load
| HPV DNA− | HPV DNAlow | HPV DNAhigh/medium | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n | (%) | n | (%) | P valuea | n | (%) | P valueb | P valuec | |
| Sex | .328 | .004 | .322 | ||||||
| Male | 41 | (93) | 13 | (81) | 19 | (66) | |||
| Female | 3 | (7) | 3 | (19) | 10 | (34) | |||
| Age | .940 | .027 | .081 | ||||||
| Mean (range) | 68.6 (54‐87) | 68.8 (59‐85) | 62.2 (37‐90) | ||||||
| Smoking | .743 | .003 | .004 | ||||||
| <20 pack‐yearsd | 3 | (7) | 0 | (0) | 8 | (28) | |||
| ≥20 pack‐years | 34 | (77) | 14 | (88) | 11 | (38) | |||
| Never | 7 | (16) | 2 | (13) | 10 | (34) | |||
| Alcohol consumption | .129 | .001 | .582 | ||||||
| <60 units of sake indexe | 9 | (20) | 5 | (31) | 9 | (31) | |||
| ≥60 units of sake index | 29 | (66) | 6 | (38) | 7 | (24) | |||
| Never | 6 | (14) | 5 | (31) | 13 | (45) | |||
| Tumor localization | .849 | .003 | .072 | ||||||
| Palatine tonsil | 22 | (50) | 10 | (63) | 26 | (90) | |||
| Base of tongue | 13 | (30) | 3 | (19) | 2 | (7) | |||
| Soft palate and uvula | 4 | (9) | 1 | (6) | 1 | (3) | |||
| Posterior wall of oropharynx | 5 | (11) | 2 | (13) | 0 | (0) | |||
| cT stagef | .108 | .211 | .463 | ||||||
| Tis | 1 | (2) | 0 | (0) | 0 | (0) | |||
| T1 | 5 | (11) | 0 | (0) | 4 | (14) | |||
| T2 | 14 | (32) | 10 | (63) | 16 | (55) | |||
| T3 | 16 | (36) | 2 | (13) | 5 | (17) | |||
| T4a | 8 | (18) | 4 | (25) | 4 | (14) | |||
| T4b | 0 | (0) | 0 | (0) | 0 | (0) | |||
| cN stagef | .360 | .01 | .080 | ||||||
| N0 | 16 | (36) | 4 | (25) | 2 | (7) | |||
| N1 | 8 | (18) | 1 | (6) | 8 | (28) | |||
| N2a | 1 | (2) | 0 | (0) | 2 | (7) | |||
| N2b | 8 | (18) | 5 | (31) | 13 | (45) | |||
| N2c | 9 | (21) | 3 | (19) | 3 | (10) | |||
| N3 | 2 | (5) | 3 | (19) | 1 | (3) | |||
| Treatment | .341 | .471 | .732 | ||||||
| Surgery | 11 | (25) | 1 | (6) | 4 | (14) | |||
| Surgery with RT or CRT | 13 | (30) | 8 | (50) | 9 | (31) | |||
| RT | 7 | (16) | 2 | (13) | 3 | (10) | |||
| CRT | 13 | (30) | 5 | (31) | 12 | (41) | |||
| Palliative care | 0 | (0) | 0 | (0) | 1 | (3) | |||
Bold indicates significant values.
Abbreviations: cN, clinical nodal; CRT, chemoradiation therapy; cT, clinical tumor; RT, radiation therapy.
P value, HPV DNA‐negative group compared with HPV DNA low‐positive group.
P value, HPV DNA‐negative group compared with HPV DNA high/medium‐positive group.
P value, HPV DNA low‐positive group compared with HPV DNA high/medium‐positive group.
One pack‐year is defined as the equivalent of smoking one pack of 20 cigarettes per day for 1 year.
One unit of sake index is defined as the equivalent of drinking 22 g alcohol per day for 1 year.
Determined based on the 7th edition of the American Joint Committee on Cancer/UICC TNM classification.