TABLE 2.
Univariate and multivariate Cox regression analyses of overall survival (OS) and progression‐free survival (PFS) in patients with oropharyngeal cancer
| OS | PFS | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
|
HR (95% CI) |
P value |
HR (95% CI) |
P value |
HR (95% CI) |
P value |
HR (95% CI) |
P value | |
| HPV16 DNA load | ||||||||
| High/medium vs negative |
5.53 (1.26‐24.2) |
.023 |
5.67 (1.12‐28.82) |
.036 |
8.36 (2.55‐27.42) |
< .001 |
7.70 (2.04‐29.12) |
.003 |
| High/medium vs low |
11.47 (2.56‐51.27) |
.001 |
11.8 (2.19‐63.66) |
.004 |
7.28 (2.05‐25.8) |
.002 |
7.72 (1.91‐31.24) |
.004 |
| Sex | ||||||||
| Female vs male |
3.73 (0.89‐15.73) |
.073 |
4.28 (1.32‐13.81) |
.015 |
2.89 (0.88‐9.54) |
.081 | ||
| Age | ||||||||
| <Mean vs >mean |
1.29 (0.62‐2.69) |
.493 |
1.40 (0.78‐2.52) |
.266 | ||||
| Smoking | ||||||||
| Never vs ever |
1.09 (0.42‐2.88) |
.855 |
1.73 (0.73‐4.10) |
.212 | ||||
| Alcohol consumption | ||||||||
| Never vs ever |
0.59 (0.27‐1.32) |
.199 |
1.14 (0.56‐2.32) |
.711 | ||||
| Tumor localization | ||||||||
|
Nonpalatine tonsil vs palatine tonsil |
0.51 (0.24‐1.07) |
.075 |
0.55 (0.30‐0.99) |
.048 |
0.88 (0.48‐1.62) |
.676 | ||
| cT stage | ||||||||
| Tis‐T1 vs T2‐T4 |
2.3 (0.55‐9.70) |
.257 |
1.71 (0.61‐4.78) |
.306 | ||||
| cN stage | ||||||||
| N0‐N1 vs N2‐N3 |
1.20 (0.56‐2.58) |
.645 |
0.94 (0.52‐1.70) |
.838 | ||||
| Treatment | ||||||||
|
Surgery (with RT or CRT) vs RT or CRT |
0.86 (0.41‐1.80) |
.686 |
1.09 (0.60‐1.95) |
.785 | ||||
| p16 | ||||||||
| Negative vs positive |
0.38 (0.16‐0.88) |
.025 |
1.02 (0.40‐2.70) |
.942 |
0.44 (0.23‐0.85) |
.014 |
1.26 (0.60‐2.62) |
.542 |
| HPV16 physical status | ||||||||
| Integrated vs episomal |
0.30 (0.06‐1.57) |
.155 |
0.46 (0.11‐1.93) |
.286 | ||||
| Integrated vs mixed |
0.56 (0.18‐1.77) |
.324 |
0.59 (0.19‐1.87) |
.370 | ||||
| Integrated vs no viral DNA |
0.70 (0.25‐1.93) |
.490 |
1.66 (0.64‐4.30) |
.296 | ||||
Bold indicates significant values.
Abbreviations: CI, confidence interval; cN, clinical nodal; CRT, chemoradiation therapy; cT, clinical tumor; HPV, human papillomavirus; HR, hazard ratio; RT, radiation therapy.