TABLE 2.

Univariate and multivariable hazard ratios for symptomatic disease by AF-ALB quartile.

Tuberculosis	Unadjusted analysis			Adjusted analysis^#			Test for trend^#
Tuberculosis	Hazard Ratio	95% CI	p value	Hazard Ratio	95% CI	p value	p value
AF-ALB Quartile 1	Ref	---	---	Ref	---	---	0.03
AF-ALB Quartile 2	0.63	0.16–2.51	0.51	0.43	0.06–2.74	0.34
AF-ALB Quartile 3	1.40	0.56–3.48	0.47	1.44	0.52–3.47	0.54
AF-ALB Quartile 4	2.55	0.99–6.58	0.05	3.39	1.34–8.11	0.01
Hepatitis B^Ψ							0.5
AF-ALB Quartile 1	Ref	---	---	Ref	---	---
AF-ALB Quartile 2	0.90	0.15–5.41	0.91	1.11	0.17–6.36	0.97
AF-ALB Quartile 3	0.41	0.04–3.92	0.44	0.36	0.06–5.22	0.59
AF-ALB Quartile 4	0.47	0.05–4.53	0.51	0.37	0.04–7.03	0.51
Malaria
AF-ALB Quartile 1	Ref	----	---	Ref	----	---	0.42
AF-ALB Quartile 2	1.12	0.52–2.42	0.78	0.98	0.47–2.04	0.96
AF-ALB Quartile 3	1.05	0.62–1.76	0.87	0.98	0.57–1.68	0.94
AF-ALB Quartile 4	0.95	0.54–1.66	0.85	0.70	0.34–1.49	0.71
Pneumonia							0.11
AF-ALB Quartile 1	Ref	----	---	Ref	----	---
AF-ALB Quartile 2	1.12	0.21–6.08	0.89	0.53	0.06–5.92	0.68
AF-ALB Quartile 3	2.40	0.73–7.90	0.15	2.50	0.77–9.21	0.12
AF-ALB Quartile 4	1.68	0.41–6.79	0.47	1.59	0.48–9.07	0.33

AF-ALB Quartile 1 0.093>0.685 pmol/mg albumin, AF-ALB Quartile 2 0.685≥ 0.939 pmol/mg albumin, AF-ALB Quartile 3 0.939 ≥ 1.407 pmol/mg albumin, AF-ALB Quartile 3 1.407 ≥ 3.48 pmol/mg albumin

Adjusted for HIV viral load, and CD4 count

^Ψ

Hepatitis B analysis was treated as single even