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. Author manuscript; available in PMC: 2022 Aug 12.
Published in final edited form as: J Med Chem. 2021 Jul 19;64(15):10997–11013. doi: 10.1021/acs.jmedchem.1c00367

Figure 3. Compound 7 and the H3K27cr peptide occupy the same binding site of the ENL YEATS domain.

Figure 3.

Superimposed 1H,15N HSQC spectra of His-ENL collected as H3K27cr (H3 residues 22–31, left) or 7 (right) was added stepwise. Spectra are color-coded according to the protein:ligand molar ratios.