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. Author manuscript; available in PMC: 2022 Aug 12.
Published in final edited form as: J Med Chem. 2021 Jul 19;64(15):10997–11013. doi: 10.1021/acs.jmedchem.1c00367

Figure 4. Compounds 7, 11, and 24 are highly specific to ENL over other YEATS domains.

Figure 4.

(A) Peptide pulldowns of ENL, AF9, YEATS2, and GAS41 with the indicated acylated histone peptides with or without 1, 7, 11, and 24. Unmodified histone peptides were used as negative controls to the acylated peptides and DMSO as a negative control to compound treatment. (B) AlphaScreen measurement of IC50 of 1, 7, 11, and 24 in inhibition of YEATS domains binding to the corresponding acylated histone peptides as in (A). Data represent mean ± SEM, n = 4.