Fig. 1.
Identification of putative cNMP binding proteins in T. cruzi. 27 proteins were identified in the parasite genome using a combination of search methods: HMMER and BLAST for local similarity and Smart and Prosite as databases for protein domains. Proteins were identified by at least two of the previously mentioned techniques and listed according to the Pfam E-values, in descending order. In blackand grey the cNMP binding domains detected by Pfam database (http://pfam.sanger.ac.uk) are shown. Inyellow the cNMP binding domains according to SmartDB (http://smart.embl-heidelberg.de/help/smart_about.shtml) are shown. Bracketsonthe left indicate pairs of paralogs; due to the hybrid genotype of the T. cruzi CL Brener clone. H, haplotype; E, Esmeraldo-like; N-E, Non-Esmeraldo-like; N/A, not available. Green IDs, protein kinases. Red and orange IDs: potential cAMP-binding proteins analysed inthis study.