Table 1.
Phenotype of CXCR5+CD8+ T cell Subsets by Function
| CD8+ T cell subsets | ||||||||
|---|---|---|---|---|---|---|---|---|
| CXCR5+CD8+ T cells Evidence for Antibody Regulation |
CXCR5+CD8+ T Cells Antibody Regulation Not Reported |
CD8+ T Regulatory cells (for reference) |
||||||
| Effector Function | Antibody-enhancer** | Antibody-Suppression | Anti-viral | Anti-tumor | CD8+ T regs | |||
| Qa-1-restricted (Anti-autoimmune) |
Follicular regulatory (Anti-Viral immunity) |
Antibody-suppressor (Transplant Alloimmunity) |
||||||
| Transcription factors | Bcl-6 | (30, 31, 34–37) | nr | nr | * | (9, 12, 17, 20, 73) | (74) | nr |
| Tbet | (30, 35) | nr | nr | * | (19) | nr | nr | |
| Tcf1 | (30) | nr | nr | * | (19) | nr | nr | |
| Eomes | (30, 38) | (59) | nr | * | (19) | (74) | (44) | |
| FoxP3 | nr | (58) | nr | (51) | nr | nr | (44, 45) | |
| Co-inhibitory molecules | PD-1 | (23, 31, 33–35) | (58) | nr | (51) | (8, 12, 18, 19, 66, 73, 75) | (24, 74, 76) | (46) |
| Tim-3 | (33) | nr | (55) | * | (9, 18, 19) | (24) | nr | |
| CTLA-4 | (33) | (58) | nr | * | (17) | (76) | (44, 45) | |
| Co-stimulatory molecules | CD27 | (32, 36) | nr | nr | * | nr | (74, 76) | nr |
| CD28 | (32, 38) | nr | nr | * | (73) | (74) | (47, 48) | |
| CD40L | (31, 36) | nr | nr | * | (12) | nr | nr | |
| ICOS | (23, 31, 32, 34, 35) | nr | nr | * | (9, 20, 73) | nr | (45) | |
| ICOSL | nr | (58) | nr | (51) | (9) | nr | nr | |
| Cytokines | IFN-γ | (30, 32, 33, 35–37, 39) | nr | nr | (51, 53, 54) | (12, 18, 66) | (22, 76, 77) | (49) |
| IL-10 | (39) | (57) | (55) | (51) | (17, 66) | (77) | (46) | |
| IL-21 | (31, 33–36, 39) | nr | nr | * | (12) | nr | nr | |
| Effector molecules | Perf | (32, 34, 36) | (58) | (55) | (52) | (18) | (76, 78) | (45) |
| Gzmb | (34, 36) | nr | nr | * | (18) | (22, 24, 76, 78) | (45) | |
| Chemokine Receptor | CXCR5 | (30, 31, 34–37) | (58) | (55) | (51, 53) | (9, 12, 17, 19, 20, 73) | (20, 23, 24, 74, 76) | nr |
Red highlight = Positive expression; Green highlight = Not expressed.
*
Unpublished data; nr = Not reported
**
CXCR5+CD8+ T cells enhance antibody in models of viral infection, autoimmunity, and tumor