. Author manuscript; available in PMC: 2022 Jun 15.

Published in final edited form as: J Immunol. 2021 Jun 15;206(12):2775–2783. doi: 10.4049/jimmunol.2100082

Table 2.

Clinical Correlations and Phenotype of Human CXCR5⁺CD8⁺ T cell subsets

	Clinical Condition/Number of Patients (n)	CXCR5⁺CD8⁺ T cell phenotype	CXCR5⁺CD8⁺ T cell Clinical Correlation	Reference
Anti-viral	HIV (n=36)	IL-2⁺IFN-γ⁺IL-17⁺	High circulating CXCR5⁺CD8⁺ T cell quantity correlates with HIV neutralization by plasma from HIV-infected children	(64)
	HIV (n=115)	CCR7^−/loCD62L^hiIL-21^hi TCF1^hiBCL6^hiBLIMP1⁻	High circulating CXCR5⁺CD8⁺ T cell quantity correlates with reduced HIV viral load	(63)
	HIV (n=101)	PD-1⁺	High circulating HIV-specific CXCR5⁺CD8⁺ T cell quantity correlates with reduced HIV viral load	(8)
	HIV (n=14)	PD-1⁺CD44⁺KLRG1⁺ IFN-γ⁺CD107a⁺	High circulating HIV-specific CXCR5⁺CD8⁺ T cell quantity correlates with reduced HIV viral load	(18)
	Dengue Virus 2 (n=57)	PD-1⁺	High circulating anti-viral CXCR5⁺CD8⁺ T cell quantity correlates with reduced viral load and protection from associated kidney injury	(66)
Bacterial Infection	Bacterial Pneumonia (n=65)	PD-1⁺CD103^lo	High circulating CXCR5⁺CD8⁺ T cell quantity correlates with exacerbation of pneumonia severity	(67)
Anti-tumor	Colorectal cancer (n=44)	PD1^hiTim3^hiLAG3^hi IFN-γ^hiTNF-α^hiIL-2^hi PRF1^hiGZMB^hi	High CXCR5⁺CD8⁺ T cell quantity in tumors or tumor draining lymph nodes correlates with increased cancer-free survival times	(22)
	HCC (n=40)	PD-1^hiICOS^hi IL-21^hi	High tumor-infiltrating CXCR5⁺CD8⁺ T cell quantity negatively correlates with microvascular invasion, TNM staging and early recurrence	(23)
	Pancreatic cancer (n=12)	PD-1⁺TIM-3⁺	High tumor-infiltrating and circulating CXCR5⁺CD8⁺ T cell quantity correlates with disease-free survival after tumor resection	(68)
	Bladder cancer (n=11, fresh tissue for flow cytometry; n=249 bioinformatics gene signature)	PD-1⁺CTLA-4⁺ CD62L⁺LAG3⁺ IFN-γ⁺GZMB⁺ TNF-α⁺CD107a⁺	High tumor-infiltrating CXCR5⁺CD8⁺ T cell quantity correlates with lower tumor stage and prolonged overall survival and cancer-free survival	(69)
	Follicular (Germinal Center B cell) lymphoma (n=187, bioinformatics gene expression)	PD-1⁺IFN-γ⁺TNF-α⁺	High tumor expression of CXCR5⁺CD8⁺ T cell signature genes correlates with prolonged survival	(70)
Autoimmunity	SLE (n=79)	CD158e⁺ (Inhibitory, Killer cell Ig-like receptor, KIR⁺)	Reduced quantity of circulating CD158e⁺CD8⁺ T cells in SLE patients compared to healthy controls; KIR⁺CD8⁺ T cells potential human counterpart to murine Ly49⁺ Qa-1-restricted CD122^hiCD8⁺ T cell related to protection from autoimmunity	(59)
Transplantation	Kidney Transplant (n=95)	CD44⁺CD62L⁻IFN-γ⁺	High circulating CXCR5⁺CD8⁺ T cell quantity correlates with lower incidence of de novo donor specific antibody production and improved clinical outcomes at 1 year post transplant	(53)