Table 1. Antimuscarinic agents for adults with OAB.
Starting dose regimen* | Dose escalation* | |
---|---|---|
Darifenacin | 7.5mg | 15mg |
Fesoterodine | 4mg | 8mg |
Imidafenacin | 0.1mg bid | 0.2mg bid |
Oxybutynin** | 10mg ER or 5mg IR bid or tid | 115-20mg ER or 5mg qid |
Propiverine** | 30mg ER or 15mg IR bid | 45mg ER or 15mg IR tid |
Solifenacin | 5mg | 10mg |
Tolterodine | 4mg ER or 2mg IR bid | Not evaluated |
Trospium | 60mg ER or 20mg bid | Not evaluated |
Recommended initial dose for adults with no liver or renal function impairment; Unless noted, regimens are once-daily dosing; bid: twice a day; tid: three times a day; IR: immediate release; ER: extended release;
Agents with mixed mechanism of action but predominant antimuscarinic action.