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Adverse reaction of 33 advanced CRC patients treated with regorafenib and toripalimab as third-line or above.
| Adverse reaction | Grade (n) | Proportion (%) | ||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | Grades1–4 | Grade3/4 | |
| Fatigue | 5 | 2 | 0 | 0 | 21.21 | 0 |
| Hypertension | 3 | 1 | 0 | 0 | 12.12 | 0 |
| Hypothyroidism | 7 | 1 | 0 | 0 | 24.24 | 0 |
| Hand-foot syndrome | 8 | 2 | 1 | 0 | 33.33 | 3.03 |
| Leukopenia | 5 | 0 | 0 | 0 | 15.15 | 0 |
| Platelet count decreased | 1 | 1 | 0 | 0 | 6.06 | 0 |
| Myocarditis | 0 | 0 | 0 | 1 | 3.03 | 3.03 |
| Liver dysfunction | 7 | 1 | 1 | 0 | 27.27 | 3.03 |
| Fever | 6 | 2 | 0 | 0 | 24.24 | 0 |
| Diarrhea | 0 | 1 | 0 | 0 | 3.03 | 0 |
