Table 5.
The association between total bilirubin concentrations and mean telomere length in different subgroups.
| Total bilirubin, mg/dL | Q1 (n = 1621) | Q2 (n = 1210) | Q3 (n = 1862) | Q4 (n = 1744) | Q5 (n = 1381) | ||||
|---|---|---|---|---|---|---|---|---|---|
| β (95% CI) | P value | β (95% CI) | P value | β (95% CI) | P value | β (95% CI) | P value | ||
| Age, year | |||||||||
| <45 | Ref | 0.04 (0.00, 0.07) | 0.026 | 0.05 (0.02, 0.08) | <0.001 | 0.04 (0.01, 0.07) | 0.006 | 0.04 (0.01, 0.07) | 0.013 |
| 45-<60 | Ref | 0.06 (0.01, 0.10) | 0.008 | 0.08 (0.04, 0.11) | <0.001 | 0.05 (0.01, 0.08) | 0.011 | 0.05 (0.01, 0.09) | 0.007 |
| ≥60 | Ref | -0.02 (-0.05, 0.00) | 0.103 | 0.00 (-0.02, 0.03) | 0.756 | -0.00 (-0.03, 0.02) | 0.780 | -0.01 (-0.03, 0.02) | 0.691 |
| Body mass index, kg/m2 | |||||||||
| <18.5 | Ref | 0.02 (-0.20, 0.24) | 0.885 | 0.17 (-0.02, 0.37) | 0.086 | -0.04 (-0.23, 0.15) | 0.696 | 0.01 (-0.19, 0.21) | 0.910 |
| 18.5- <25 | Ref | 0.01 (-0.04, 0.05) | 0.741 | 0.06 (0.02, 0.10) | 0.003 | 0.04 (0.00, 0.08) | 0.032 | 0.04 (-0.00, 0.08) | 0.078 |
| 25- <30 | Ref | 0.03 (0.00, 0.06) | 0.025 | 0.03 (0.01, 0.06) | 0.018 | 0.04 (0.01, 0.07) | 0.007 | 0.03 (-0.00, 0.06) | 0.075 |
| ≥30 | Ref | 0.01 (-0.01, 0.04) | 0.337 | 0.04 (0.02, 0.07) | 0.002 | 0.03 (-0.00, 0.06) | 0.064 | 0.04 (0.01, 0.08) | 0.012 |
| Smoke status, % | |||||||||
| None | Ref | 0.02 (-0.00, 0.05) | 0.097 | 0.04 (0.02, 0.07) | 0.001 | 0.03 (0.01, 0.06) | 0.012 | 0.02 (-0.01, 0.05) | 0.127 |
| Past | Ref | 0.02 (-0.01, 0.06) | 0.160 | 0.04 (0.01, 0.07) | 0.017 | 0.05 (0.02, 0.08) | 0.003 | 0.05 (0.02, 0.08) | 0.003 |
| Current | Ref | 0.02 (-0.02, 0.05) | 0.378 | 0.07 (0.03, 0.10) | <0.001 | 0.03 (-0.01, 0.07) | 0.098 | 0.06 (0.02, 0.10) | 0.005 |
| Energy intake, kcal | |||||||||
| Q1 | Ref | 0.01 (-0.03, 0.04) | 0.687 | 0.05 (0.01, 0.08) | 0.005 | 0.03 (-0.01, 0.06) | 0.155 | 0.04 (0.00, 0.08) | 0.050 |
| Q2 | Ref | 0.03 (-0.01, 0.06) | 0.159 | 0.03 (-0.00, 0.06) | 0.074 | 0.01 (-0.02, 0.04) | 0.546 | 0.02 (-0.02, 0.06) | 0.283 |
| Q3 | Ref | 0.04 (0.01, 0.08) | 0.020 | 0.06 (0.03, 0.10) | <0.001 | 0.04 (0.01, 0.08) | 0.011 | 0.03 (-0.00, 0.07) | 0.054 |
| Q4 | Ref | 0.01 (-0.02, 0.05) | 0.536 | 0.05 (0.01, 0.08) | 0.005 | 0.04 (0.01, 0.08) | 0.009 | 0.05 (0.01, 0.08) | 0.008 |
| Alcohol use, % | |||||||||
| No | Ref | 0.02 (0.00, 0.04) | 0.027 | 0.05 (0.03, 0.07) | <0.001 | 0.03 (0.01, 0.05) | 0.002 | 0.04 (0.02, 0.06) | <0.001 |
| Yes | Ref | 0.01 (-0.02, 0.05) | 0.455 | 0.04 (0.00, 0.07) | 0.039 | 0.03 (-0.00, 0.07) | 0.062 | 0.03 (-0.01, 0.06) | 0.156 |
| Physical activity, MET/week | |||||||||
| No aerobic activity | Ref | 0.02 (-0.02, 0.06) | 0.329 | 0.04 (0.00, 0.08) | 0.032 | 0.04 (0.00, 0.08) | 0.047 | 0.04 (-0.01, 0.08) | 0.094 |
| Low activity | Ref | 0.04 (0.01, 0.08) | 0.013 | 0.06 (0.03, 0.09) | <0.001 | 0.04 (0.01, 0.08) | 0.008 | 0.04 (0.01, 0.08) | 0.017 |
| Moderate activity | Ref | -0.00 (-0.05, 0.04) | 0.992 | 0.07 (0.03, 0.11) | 0.001 | 0.04 (0.00, 0.08) | 0.049 | 0.03 (-0.02, 0.07) | 0.221 |
| High activity | Ref | 0.03 (-0.01, 0.07) | 0.092 | 0.05 (0.02, 0.08) | 0.005 | 0.03 (-0.00, 0.07) | 0.076 | 0.04 (0.00, 0.08) | 0.039 |
| Diabetes, % | |||||||||
| No | Ref | 0.03 (0.01, 0.05) | 0.012 | 0.05 (0.03, 0.07) | <0.001 | 0.04 (0.02, 0.06) | <0.001 | 0.03 (0.01, 0.05) | 0.001 |
| Yes | Ref | -0.01 (-0.05, 0.04) | 0.782 | 0.02 (-0.02, 0.07) | 0.294 | 0.03 (-0.02, 0.08) | 0.289 | 0.05 (-0.00, 0.10) | 0.065 |
| Hypertension, % | |||||||||
| No | Ref | 0.02 (-0.00, 0.05) | 0.063 | 0.05 (0.02, 0.07) | <0.001 | 0.05 (0.03, 0.07) | <0.001 | 0.04 (0.02, 0.06) | 0.001 |
| Yes | Ref | 0.02 (-0.01, 0.05) | 0.297 | 0.05 (0.02, 0.07) | 0.001 | 0.01 (-0.02, 0.04) | 0.567 | 0.03 (0.00, 0.06) | 0.043 |
| C-reactive protein | |||||||||
| Q1 | Ref | 0.03 (-0.01, 0.08) | 0.144 | 0.06 (0.01, 0.10) | 0.008 | 0.04 (-0.00, 0.08) | 0.074 | 0.05 (0.01, 0.09) | 0.024 |
| Q2 | Ref | 0.02 (-0.01, 0.05) 0.1843 | 0.184 | 0.04 (0.02, 0.07) | 0.002 | 0.05 (0.02, 0.07) | <0.001 | 0.02 (-0.01, 0.05) | 0.133 |
| Q3 | Ref | 0.01 (-0.01, 0.04) | 0.326 | 0.04 (0.02, 0.07) | <0.001 | 0.03 (-0.00, 0.05) | 0.059 | 0.05 (0.01, 0.08) | 0.007 |
∗Adjusted model adjust for age (continuous), race (non-Hispanic white, black, Mexican American, other Hispanic, other race/ethnicity or missing), education (less than high school, high school, more than high school, or missing), body mass index (<18.5, 18.5- <25, 25- <30, ≥30, or missing), smoke status (none, past, current, or missing), alcohol (yes, no, or missing), physical activity (no aerobic activity, low activity, moderate activity, high activity, or missing), energy intake (Q1-Q4), diabetes (yes, no, or missing), hypertension (yes, no, or missing), and C-reactive protein (Q1-Q3).