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Quercetin (Que) reduces high-glucose- (HG-) induced HL-1 inflammation injury by promoting SIRT5-related desuccinylation. (a) Immunoblotting and succinylation of IDH2. RT-PCR was used to detect (b) SIRT5 and (c) IDH2 mRNA expression. (d) IDH2 succinylation. (e–g) Activities of mitochondrial respiratory complexes I/III and IV were detected using ELISA. Mean ± SD; ∗P < 0.05.
